Fluoxetine-trazodone

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Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from fluoxetine to trazodone.

Nietinrijdenbord.png Stop fluoxetine
  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.
Eenrichtingbord.png Start trazodone
  • Day 2-22: A wash-out period is needed.
  • Day 23: Start trazodone in a dosage of 100-150 mg/day.
  • After day 29: If necessary, increase gradually the dosage of trazodone to a maximum of 400 mg/day.
Infobord.png More information
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Fluoxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary for at least four weeks.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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