Switch medication from fluvoxamine to vortioxetine.
- Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
- Day 1: when a dosage of 50 mg/day is reached, stop administration
- A wash-out period is not necessary, but care is needed.
- Day 1: start administration of vortioxetine in a dosage of 10 mg/day.
- Fluvoxamine is a strong inhibitor of CYP2C, which metabolizes vortioxetine.
- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
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