Hypericum-tranylcypromine

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Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from hypericum to tranylcypromine.

Nietinrijdenbord.png Stop hypericum
  • Day 1: Decrease the original dose with about 25% every 3 days.
Eenrichtingbord.png Start tranylcypromine
  • Day 15-22: A wash-out period of at least one week is necessary..[1][2][3][4]
  • Day 23: Start with about 25% of the target dose.
  • Day 38: Increase with about 25% of the target dose every 3 days.
Letopbord.png Cave
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[5]
  • The T1/2 of hypericum is 19 - 37 hour.[4]
  • No severe interactions are known.
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