Imipramine-escitalopram

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Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from imipramine to escitalopram.

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1-3: reduce dosage of imipramine to 50 mg/day.
  • Day 4-7: reduce dosage of imipramine to 25 mg/day.
  • Day 8: stop administration of imipramine.
Eenrichtingbord.png Start escitalopram
  • Day 1: simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
Infobord.png More information
  • Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes imipramine.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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