Mianserine-duloxetine

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Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from mianserine to duloxetine.

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Eenrichtingbord.png Start duloxetine
  • Day 1: simultaneously start duloxetine in a low dosage of 30 mg/day.
  • Day 8: stop administration of mianserine and only continue administration of duloxetine in a dosage of 60 mg/day.
  • If necessary, increase the dosage of duloxetine.
Infobord.png More information
  • Caution with this switch is necessary, because duloxetine slows the metabolism of mianserine via CYP2D6.
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