Mianserine-escitalopram

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Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from mianserine to escitalopram.[1] [2]

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
  • Day 8: stop administration of mianserine.
Eenrichtingbord.png Start escitalopram
  • Day 1: simultaneously start escitalopram in a normal dosage of 10 mg/day.
  • If necessary, increase the dosage of escitalopram.
Infobord.png More information
  • Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes mianserine.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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