Mianserine-paroxetine

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Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from mianserine to paroxetine.

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Eenrichtingbord.png Start paroxetine
  • Day 1: simultaneously start paroxetine in a normal dosage of 20 mg/day.
  • Day 8: stop administration of mianserine and only continue administration of paroxetine.
  • If necessary, increase the dosage of paroxetine .
Infobord.png More information
  • Caution with this switch is necessary, because paroxetine slows the metabolism of mianserine via CYP2D6.
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