Mianserine-sertraline

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Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from mianserine to sertraline.

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Eenrichtingbord.png Start sertraline
  • Day 1: simultaneously start sertraline in a normal dosage of 50 mg/day.
  • Day 8: stop administration of mianserine and only continue administration of sertraline.
  • If necessary, increase the dosage of sertraline.
Infobord.png More information
  • Caution with this switch is necessary, because sertraline dose-dependently slows the metabolism of mianserine via CYP2D6.
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