Moclobemide-doxepine

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Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from moclobemide to doxepin.

Nietinrijdenbord.png Stop moclobemide
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait for about 24 hour as a washout period
Eenrichtingbord.png Start doxepin
  • Start with the initial dose
Infobord.png More information
  • Because of the short half life of moclobemide (approx. 2h), the next antidepressant can start next day after stopping with moclobemide.[3]
  • “Start low, go slow” is not required, but caution is necessary.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2015; Monografie "doxepine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 63 (dutch)
  3. Keks, Nicholas, J. Hope, and S. Keogh. "Switching and stopping antidepressants." Australian Prescriber 39.3 (2016).
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