Nortriptyline-maprotiline

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Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from nortriptyline to maprotiline.

Nietinrijdenbord.png Stop nortriptyline
  • Before day 1: gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
  • Day 1: reduce dosage of nortriptyline to 50 mg/day.
  • Day 3: reduce dosage of nortriptyline to 25 mg/day.
  • Day 8: stop administration of nortriptyline.
Eenrichtingbord.png Start maprotiline
  • No wash-out period is needed.
  • Day 9: start administration of maprotiline in a normal dosage of 25-75 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • Actually maprotiline is a TCA with a carbon bridge, so it is also called TetraCyclicAntidepressant.
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