Paliperidone LA-Clozapine

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Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone
Clozapine
Type Antipsychotic
Group Atypical AP
links
Medscape Clozapine
PubChem 2818
PubMed Clozapine
Kompas (Dutch) Clozapine
Wikipedia Clozapine

Switch medication from Paliperidone_LA to Clozapine.

Nietinrijdenbord.png Stop Paliperidone_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Clozapine
  • Day 31-33: start with 12,5 mg at night
  • Day 34-36 25 mg in divided doses
  • From day 37: increase daily dose every 1-2 day(s) with 25 mg
  • Low dose in the morning, high dose at night (twice daily dosage)
  • Increments are dependent on the status of patient
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    StopDepotRispStartOralCloz.jpg
Nietinrijdenbord.png — Paliperidone_LA
Eenrichtingbord.png — Clozapine


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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