Paroxetine-clomipramine

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paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from paroxetine to clomipramine.

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start clomipramine

Caution is necessary.

  • Day 9: start administration of clomipramine in a low dosage of 25-50 mg/day.
  • Day 16: increase dosage of clomipramine to 50-100 mg/day.
  • Day 29: if necessary, increase dosage of clomipramine.
Infobord.png More information
  • Paroxetine slows the metabolism of clomipramine via CYP2D6.
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