Switch medication from Partial antagonist to Clozapine.
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.
Stop Partial antagonist
- Day 1-21: Continue drug at usual dose
- Day 22: Stop drug
- Day 1: start with 12,5 mg at night
- Day 2: 25 mg in divided doses
- Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
- Day 16-28: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
— Partial antagonist — Clozapine
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