Switch medication from Partial antagonist to Quetiapine.
Partial antagonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial antagonist' group from anotherdrug should be read as partial antagonist-anotherdrug. Similarly, a switch from a member of the 'partial antagonist' group to anotherdrug should be read as anotherdrug-partial antagonist.
Stop Partial antagonist
- Day 1-21: Continue drug at usual dose
- Day 22: Stop drug
- Day 1-4: approx. 25% of target dose
- Day 5-8: approx. 50% of target dose
- Day 9-12: approx. 75% of target dose
- Day 13: target dose
- Day 28: Reevaluate dose, if necessary adjust dose
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
— Partial antagonist — Quetiapine
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