Pimozide-Rest AP

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Pimozide
Type Antipsychotic
Group Diphenylbutylpiperidines
links
Medscape Pimozide
PubChem 16362
PubMed Pimozide
Kompas (Dutch) Pimozide
Wikipedia Pimozide
Rest anti-psychotics

Chlorprothixene
Flupentixol
Loxapine
Paliperidone
Pericyazine
Perphenazine
Trifluoperazine
Zuclopenthixol

Switch medication from Pimozide to Rest AP.

Nietinrijdenbord.png Stop Pimozide
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Rest AP
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
    Switchstandaardup en down.jpg
Nietinrijdenbord.png — Pimozide
Eenrichtingbord.png — Rest AP


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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