Rest AP-Quetiapine

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Rest anti-psychotics

Chlorprothixene
Flupentixol
Loxapine
Paliperidone
Pericyazine
Perphenazine
Trifluoperazine
Zuclopenthixol

Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Switch medication from Rest AP to Quetiapine.

Nietinrijdenbord.png Stop Rest AP
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Quetiapine
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[5]
    Switchstandaardup en down.jpg
Nietinrijdenbord.png — Rest AP
Eenrichtingbord.png — Quetiapine


  1. 1.0 1.1 1.2 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 73 (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. Drugs.com quetiapine-fumarate
  5. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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