Switch medication from Risperidone_LA to Clozapine.
- Day 1: Last depot injection
- Day 28: start with 12,5 mg at night
- Day 29: 25 mg in divided doses
- Day 30-42: increase daily dose every 1-2 day(s) with 25 mg
- Day 43-55: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
- Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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