Switch medication from sertraline to venlafaxine.
- Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
- Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
- Day 8: Stop administration of sertraline
- No wash-out period is needed.
- Day 9: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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