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| to = agomelatine
| stop =
* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine further to 25 mg/day.* '''Day 8:''' stop administration of fluvoxamine.
| start =
* '''Day 18-714:''' a wash-out period of one week is necessary.* '''Day 815:''' start administration of agomelatine after this period in a dosage of 25 mg/day.
* If necessary, the dosage of agomelatine can be increased to 50 mg/day.
| info =
* Fluvoxamine stops the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).}}
