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* '''Before day 0:''' gradually reduce dosage of nortriptyline to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
* '''Day 1-3:''' reduce dosage of nortriptyline to 25 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of nortriptyline according to the scheme above.
* '''Day 8:''' stop administration of nortriptyline and continue administration of bupropion only in a dosage of 300 mg/day.
| info =
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
* Caution with this switch is necessary. }}