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* '''Before day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50 mg/day.
* '''Day 1:''' reduce dosage of amitriptyline to 25 mg/day.
* '''Day 38:''' reduce dosage of stop amitriptyline to 10 mg/day.
| start =
Caution is necessary.
* '''Day 18:''' simultaneously start administration of mirtazapine in a normal dosage of 30 mg/day.* '''Day 815:''' stop administration of amitriptyline and continue if necessary, increase administration of mirtazapine.}}
