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* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
* Start according to the general dosing advice. Monitoring of the pharmacologic response and serum valproate levels is recommended. <ref name="drugscom">{{DRUGSCOMDrugscominteract|olanzapinerisperidone-with-valproic-acid-2019-0-2286-0|risperidone|valproic acid}}</ref>
| cave =
* Dose-related generalised oedema is reported. <ref> {{Pubmed|9921707|Sanders and Lehrer, Edema associated with addition of risperidone to valproate treatment. J Clin Psychiatry. 1998 Dec;59(12):689-90.}}</ref>
* Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
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