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Created page with '{{Drugcombi | base = risperidone | add = carbamazepine | info = * Risperidone is principally metabolized by CYP2D6 to an active metabolite. * Carbamazepine is principally metabo...'
{{Drugcombi
| base = risperidone
| add = carbamazepine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">
{{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy.
}}
| base = risperidone
| add = carbamazepine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with carbamazepine may decrease the plasma concentrations of risperidone and its pharmacologically active metabolite, 9-hydroxyrisperidone.
* Risperidone should be given at higher dosage to control psychotic symptoms. <ref name="drugscom">
{{Drugscominteract|risperidone-with-carbamazepine|risperidone|carbamazepine}}</ref>
| cave =
* Pharmacologic response and plasma risperidone levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy.
}}
