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Created page with '{{Drugcombi | base = gabapentin | add = valproic acid | info = * Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted ...'
{{Drugcombi
| base = gabapentin
| add = valproic acid
| info =
* Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
| start =
* Start valproic acid according to the general dosing advice.
| cave =
}}
| base = gabapentin
| add = valproic acid
| info =
* Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
| start =
* Start valproic acid according to the general dosing advice.
| cave =
}}
