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* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after intiation initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[ Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>

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