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* '''Day 116:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 1523:''' continue administration of agomelatine. If if necessary, gradually increase dosage of agomelatine to 50 mg/daytarget dose.
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
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