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Fluoxetine-clomipramine

230 bytes removed, 15:35, 28 October 2015
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| to = clomipramine
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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration{{stopFluoxetine1}}.
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Caution is necessary for at least four weeks.
* '''Day 12:''' start administration of clomipramine in a low dosage of 25 mg/day.* '''Day 89:''' increase dosage of clomipramine to 50 mg/day.* '''Day 2829:''' gradually increase dosage of clomipramine to 75 mg/day and more.
| info =
* Fluoxetine and norfluoxetine slow the metabolism of clomipramine via CYP2D6.
* Norfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.{{longt1/2fluvox}}
* Start low, go slow for clomipramine.
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