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Doxepine-bupropion

666 bytes added, 09:25, 6 May 2009
Created page with '{{Drugswitch | from = doxepin | to = bupropion | stop = * '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/ day, when this dosage is > 100 mg/day...'
{{Drugswitch
| from = doxepin
| to = bupropion
| stop =
* '''Before day 0:''' gradually reduce dosage of doxepin to a maximum of 100 mg/ day, when this dosage is > 100 mg/day.
* '''Day 1-3:''' reduce dosage of doxepin to 50 mg/day.
* '''Day 4-7:''' reduce dosage of doxepin to 25 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of doxepin according to the scheme above.
* '''Day 8:''' stop administration of doxepin and continue administration of bupropion only in a dosage of 300 mg/day.
| info =
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes doxepin. }}
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