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Imipramine-agomelatine

288 bytes removed, 12:47, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day. * '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 8:''' reduce dosage of imipramine to 25 mg/day.* '''Day 15:''' stop administration of imipramine.{{stopImipramine}}
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* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 158:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
 
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