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Clomipramine-duloxetine

266 bytes removed, 13:11, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1-7:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop administration of clomipramine. {{stopClomipramine}}
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* '''Day 89-1415:''' a wash-out period of one week is necessary.* '''Day 1516:''' start administration of duloxetine in a normal dosage of 60 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine.
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