Changes

| stop = {{stopFluvoxamineStopSSRI,SNRI}}

Caution is necessary.* '''Day 1:''' simultaneously start administration of dosulepine in a low dosage of 50 mg25mg/day.* '''Day 8:''' stop administration of fluvoxamine and continue administration increase dosage of dosulepine only. If necessary, increase to a dosage of dosulepine75 mg/day. * Start low, go slow!

* Fluvoxamine is an inhibitor fluvoxamine slows the metabolism of CYP1A2, dosulepine via CYP2C19 and CYP3A4 (moderate), which metabolize dosulepineinhibition.* {{SSCYPinh}}* {{TCAplasmalevelmonitoring}}