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  • Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase.[1]
  • Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.[2][3]
  • Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory).[2][3]
  • These two agents have less significant pharmacologic interactions than do lamotrigine and valproate.[2][3]