Trazodone-clomipramine

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Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from trazodone to clomipramine.

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 3: reduce dosage of trazodone to 50 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start clomipramine
  • No wash-out period is needed.
  • Day 9: start administration of clomipramine in a dosage of 50 mg/day.
  • Day 16: increase dosage of clomipramine to 75 mg/day.
  • Start low, go slow.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
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