Trazodone-duloxetine

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Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from trazodone to duloxetine.

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 3: reduce dosage of trazodone to 50 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start duloxetine
  • A wash-out period is not necessary, but care is needed.
  • Day 9: start administration of duloxetine in a normal dosage of 60 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
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