Trazodone-sertraline

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Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from trazodone to sertraline.

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 3: reduce dosage of trazodone to 50 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start sertraline
  • Day 8-14: wash-out period
  • Day 15: start administration of sertraline in a normal dosage of 50 mg/day.
Infobord.png More information
  • Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
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