Psychiatrienet - User contributions [en]

Moclobemide-nortriptyline

2009-05-08T13:10:20Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = nortriptyline
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is necessary.
* '''Day 9:''' start nortriptyline after this period in a normal dosage of 50 mg/day.
* “Start low, go slow” is not required, but caution is necessary.}}

Moclobemide-maprotiline

2009-05-08T13:09:49Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = maprotiline
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is necessary.
* '''Day 9:''' start maprotiline after this period in a normal dosage of 25-75 mg/day.
* “Start low, go slow” is not required, but caution is necessary.}}

Moclobemide-imipramine

2009-05-08T13:09:26Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = imipramine
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is needed.
* '''Day 9:''' start administration of imipramine the next day in a normal dosage of 25-75 mg/day.}}

Moclobemide-doxepine

2009-05-08T13:09:05Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = doxepin
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is necessary.
* '''Day 9:''' start doxepin after this period in a normal dosage of 25 mg/day.
* “Start low, go slow” is not required, but caution is necessary.}}

Moclobemide-dosulepine

2009-05-08T13:08:29Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = dosulepine
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is necessary.
* '''Day 9:''' start dosulepine after this wash-out period in a normal dosage of 50-75 mg/day.
* “Start low, go slow” is not required, but caution is necessary.}}

Moclobemide-clomipramine

2009-05-08T13:07:59Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = clomipramine
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* '''Day 8-9:''' a wash-out period of two days is needed.
* '''Day 10:''' start administration of clomipramine the next day in a low dosage of 25-50 mg/day.
* Start low, go slow.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.}}

Moclobemide-clomipramine

2009-05-08T13:07:24Z

Alexandra:

Moclobemide-bupropion

2009-05-08T13:06:47Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = bupropion
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* '''Day 8-9:''' a wash-out period of two days is necessary.
* '''Day 10:''' start bupropion after this period in a normal dosage of 150 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.}}

Citalopram-tranylcypromine

2009-05-08T13:05:18Z

Alexandra:

{{Drugswitch
| from = citalopram
| to = tranylcypromine
| stop =
* '''Day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
* '''Day 1:''' Reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day.
* '''Day 8:''' stop administration of citalopram/escitalopram.
| start =
* '''Day 8-14:''' a wash-out period of at least one week is necessary.
* '''Day 15:''' Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
* '''Day 22:''' after this week the dosage of tranylcypromine can be increased if necessary.
| info =
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
}}

Tranylcypromine-venlafaxine

2009-05-08T13:04:11Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = venlafaxine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start venlafaxine after this period in a low dosage of 37,5 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Moclobemide-amitriptyline

2009-05-08T13:03:51Z

Alexandra:

{{Drugswitch
| from = moclobemide
| to = amitriptyline
| stop =
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* No wash-out period is needed.
* '''Day 9:''' start administration of amitriptyline in a dosage of 50 mg/day.}}

Tranylcypromine-trazodone

2009-05-08T12:59:35Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = trazodone
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start trazodone after this period in a dosage of 100 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period, so caution is necessary.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-sertraline

2009-05-08T12:59:16Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = sertraline
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start sertralin after this period in a normal dosage of 50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-paroxetine

2009-05-08T12:58:55Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = paroxetine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start paroxetine after this period in a normal dosage of 20 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-nortriptyline

2009-05-08T12:58:29Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = nortriptyline
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start nortriptyline after this period in a low dosage of 25 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-mirtazapine

2009-05-08T12:58:06Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = mirtazapine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start mirtazapine after this period in a low dosage of 15 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-mianserine

2009-05-08T12:57:44Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = mianserine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start mianserine after this period in a low dosage of 30 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-maprotiline

2009-05-08T12:57:23Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = maprotiline
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start maprotiline after this period in a low dosage of 25 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-imipramine

2009-05-08T12:57:03Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = imipramine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start imipramine after this period in a low dosage of 25-50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-hypericum

2009-05-08T12:56:36Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = hypericum
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start hypericum after this period in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-fluvoxamine

2009-05-08T12:56:14Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = fluvoxamine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start fluvoxamine after this period in a normal dosage of 50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-fluoxetine

2009-05-08T12:55:56Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = fluoxetine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start fluoxetine after this period in a normal dosage of 20 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-duloxetine

2009-05-08T12:55:34Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = duloxetine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start duloxetine after this period in a low dosage of 30 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-doxepine

2009-05-08T12:55:16Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = doxepin
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start doxepin after this period in a low dosage of 25 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-dosulepine

2009-05-08T12:54:49Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = dosulepine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start dosulepine after this period in a low dosage of 50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-clomipramine

2009-05-08T12:54:28Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = clomipramine
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start clomipramine after this period in a low dosage of 25-50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-bupropion

2009-05-08T12:54:01Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = bupropion
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start bupropion after this period in a normal dosage of 150 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-amitriptyline

2009-05-08T12:53:50Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = amitriptyline
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-citalopram

2009-05-08T12:53:34Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = citalopram
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start citalopram/escitalopram after this period in a low dosage of 10 mg/day, resp. 5 mg/day.
| info =
* Occurrence of the serotonin syndrome is possible without the wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-bupropion

2009-05-08T12:52:54Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = bupropion
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start bupropion after this period in a normal dosage of 150 mg/day.
| info =
* Occurence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-amitriptyline

2009-05-08T12:52:35Z

Alexandra:

{{Drugswitch
| from = tranylcypromine
| to = amitriptyline
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
* When a dosage of 10 mg/day is reached, stop administration.
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day.
| info =
* Occurence of the serotonin syndrome is possible without a wash-out period.
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Tranylcypromine-agomelatine

2009-05-08T12:52:17Z

Alexandra:

{{ Drugswitch
| from = tranylcypromine
| to = agomelatine
| stop =
* '''Before day 0:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
* '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.
* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.
* '''Day 15:''' stop administration of tranylcypromine.
| start =
* '''Day 15-28:''' a wash-out period of two weeks is necessary.
* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day.
| info =
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
* Because tranylcypromine is a irrivesible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
* Occurrence of the serotonin syndrome is possible without a wash-out period.}}

Tranylcypromine-agomelatine

2009-05-08T12:46:09Z

Alexandra:

Hypericum-agomelatine

2009-05-08T09:53:11Z

Alexandra:

{{ Drugswitch
| from = hypericum
| to = agomelatine
| stop =
* The administration of hypericum can be stopped abruptly.
| start =
* Start administration of agomelatine the next day in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day. }}

Trazodone-venlafaxine

2009-05-08T08:59:24Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = venlafaxine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of venlafaxine in a normal dosage of 75 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}

Mirtazapine-fluvoxamine

2009-05-08T08:58:29Z

Alexandra:

{{Drugswitch
| from = mirtazapine
| to = fluvoxamine
| stop =
* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
* '''Day 8:''' stop administration of mirtazapine.
| start =
* '''Day 8:''' start fluvoxamine in a normal dosage of 50 mg/day.
* If necessary, increase dosage of fluvoxamine to 50-100 mg/day.
| info =
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4.}}

Fluvoxamine-mirtazapine

2009-05-08T08:57:53Z

Alexandra:

{{Drugswitch
| from = fluvoxamine
| to = mirtazapine
| stop =
* '''Before day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce fluvoxamine to a dosage of 25 mg/day.
* '''Day 8:''' stop administration of fluvoxamine.
| start =
* '''Day 8:''' start administration of mirtazapine in a low dosage of 15 mg/day for one week.
* '''Day 15:''' increase dosage of mirtazapine to normal (30 mg/day).
| info =
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. The inhibiting effect of fluvoxamine can continue up to two weeks after stopping administration.
}}

Fluvoxamine-mirtazapine

2009-05-08T08:57:18Z

Alexandra:

{{Drugswitch
| from = fluvoxamine
| to = mirtazapine
| stop =
* '''Before day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce fluvoxamine to a dosage of 25 mg/day.
* '''Day 8:''' stop administration of fluvoxamine.
| start =
* '''Day 8:''' start administration of mirtazapine in a low dosage of 15 mg/day for one week.
* '''Day 15:''' increase dosage of mirtazapine to normal (30 mg/day).
| info =
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. The inhibiting effect can continue up to two weeks after stopping fluvoxamine.}}

Mirtazapine-fluvoxamine

2009-05-08T08:54:20Z

Alexandra:

Trazodone-mirtazapine

2009-05-08T08:50:40Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = mirtazapine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of mirtazapine in a normal dosage of 15 mg/day.
* '''Day 15:''' increase dosage of mirtazapine to 30 mg/day.
}}

Trazodone-mianserine

2009-05-08T08:50:02Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = mianserine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of mianserine in a normal dosage of 30 mg/day.
* '''Day 15:''' increase dosage of mianserine to 60 mg/day.
}}

Trazodone-fluvoxamine

2009-05-08T08:43:30Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = fluvoxamine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 8:''' start administration of fluvoxamine in a normal dosage of 50 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}}

Trazodone-clomipramine

2009-05-08T08:42:14Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = clomipramine
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
No wash-out period is needed.
* '''Day 8:''' start administration of clomipramine in a dosage of 50 mg/day.
* '''Day 15:''' increase dosage of clomipramine to 75 mg/day.
* Start low, go slow.
| info =
* Occurrence of the serotonin syndrome is theoretically possible, so care is needed.}}

Trazodone-citalopram

2009-05-08T08:40:33Z

Alexandra:

{{ Drugswitch
| from = trazodone
| to = citalopram
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 8:''' start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes trazodone.}}

Tranylcypromine-agomelatine

2009-05-08T08:39:52Z

Alexandra:

{{ Drugswitch
| from = tranylcypromine
| to = agomelatine
| stop =
* '''Before day 0:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
* '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.
* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.
* '''Day 15:''' stop administration of tranylcypromine.
| start =
* '''Day 15-28:''' a wash-out period of two weeks is necessary.
* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day.
| info =
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
* Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
* Occurrence of the serotonin syndrome is theoretically possible.}}

Tranylcypromine-agomelatine

2009-05-08T08:39:39Z

Alexandra:

{{ Drugswitch
| from = tranylcypromine
| to = agomelatine
| stop =
* '''Before day 0:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
* '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.
* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.
* '''Day 15:''' stop administration of tranylcypromine.
| start =
* '''Day 15-28:''' a wash-out period of one week is necessary.
* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.
* If necessary, increase dosage of agomelatine to 50 mg/day.
| info =
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
* Because tranylcypromine is a irriverible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
* Occurrence of the serotonin syndrome is theoretically possible.}}

User talk:Alexandra

2009-05-07T14:28:49Z

Alexandra: /* Hypericum-venlafaxine */

Hoi Alexandra,

Je hebt de wiki inmiddels gevonden zie ik.

Een paar hints
* Zet in je voorkeuren (bovenin) de 'skin' op "modern" (in de standaard-skin "monobook" zijn een aantal knoppen niet zichtbaar die je nodig hebt tijdens bewerken).
* Rode links geven nog niet bestaande pagina's aan, blauwe links zijn voor reeds bestaande pagina's;
* Links maak je door er dubbele vierkante haken omheen te zetten (<nowiki>[[dit is een link]]</nowiki>);
* Kijk op [[:wp:Portaal:Hulp_en_beheer|Portaal:Hulp_en_beheer]] voor een overzicht van de mogelijkheden van de MediaWiki-software;
* Laat een berichtje op mijn [[User talk:Musys|overlegpagina]] achter om iets te vragen.

Suc6 - [[User:Musys|musys]] 13:07, 14 April 2009 (CEST)

==Citalopram-amitriptyline‎==
Hoi Alexandra,
* ik heb net wat [http://wiki.psychiatrienet.nl/index.php?title=Citalopram-amitriptyline&diff=247&oldid=244 kleine geitjes] in [[Citalopram-amitriptyline‎]] gerepareerd.
* Wat bedoel je met reps. (resp?)
- [[User:Musys|musys]] 12:21, 1 May 2009 (CEST)

Dag Arent,

* reps moet inderdaad resp. zijn. Daar zal ik op letten bij de volgende teksten.
* Bij 'citalopram - amitriptyline' zie ik alleen geen EDIT link meer, om de tekst nog te kunnen veranderen nadat het geplaatst is.
* En kan ik dan verder beginnen op deze site met plaatsen van de switch-teksten?
* '''Oxitriptan''' en '''hypericum''' mogen uit de tabel.
Mvg,--[[User:Alexandra|Alexandra]] 13:37, 1 May 2009 (CEST)

: Heb je in je [[Special:Preferences|Mijn voorkeuren]] de 'skin' op "modern" gezet?
: Wat mij betreft kun je aan de gang. Als er vragen zijn kun je die kwijt op [[User talk:Musys|overlegpagina]]. Ik zal af en toe meekijken of je - voor zover ik kan beoordelen - op de goeie weg blijft.
: Ik zal Oxitriptan en hypericum tzt weghalen; voor het invullen nu staan ze niet in de weg. Suc6 - [[User:Musys|musys]] 13:47, 1 May 2009 (CEST)

* Dat had ik inderdaad nog niet gedaan op deze site.
* Dank je. Het gaat me inderdaad aardig af.
Mvg, --[[User:Alexandra|Alexandra]] 13:50, 1 May 2009 (CEST)

Om de vrolijke mix Nederlands/Engels een beetje te dimmen heb ik het sjabloon helemaal engelstalig gemaakt (voordat er vierhonderd ingeviuld zijn... :
<pre>
{{Drugswitch
| from = citalopram
| to = clomipramine
| stop =
* Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
* Day 1: Reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
* Day 8: stop administration of citalopram/escitalopram.
| start =
* Day 8: no [[wash-out]] period is needed. Start administration of clomipramine in a low dosage of 50-75 mg/day.
* Start low, go slow!
| info =
* The same applies to [[Escitalopram]].
| caveat =
* Occurrence of [[serotonin syndrome]] is reported when a wash-out period (of one week) is not considered.
}}
</pre>

{{Drugswitch
| from = citalopram
| to = clomipramine
| stop =
* Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
* Day 1: Reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
* Day 8: stop administration of citalopram/escitalopram.
| start =
* Day 8: no [[wash-out]] period is needed. Start administration of clomipramine in a low dosage of 50-75 mg/day.
* Start low, go slow!
| info =
* The same applies to [[Escitalopram]].
| caveat =
* Occurrence of [[serotonin syndrome]] is reported when a wash-out period (of one week) is not considered.
}}
- [[User:Musys|musys]] 14:07, 1 May 2009 (CEST)

==Paar vraagjes==
* Is het een goed idee om eerst de zo verschillend mogelijke switches in te vullen in plaats van citalopram->alle andere (knip/plak)
* Wat is/zijn de doelgroep(en) voor de informatie (huisarts/psychiater/apotheker/patient) De informatie wordt nu voor de hele wereld zichtbaar.
* Moet er bronvermelding bij?
- [[User:Musys|musys]] 14:50, 1 May 2009 (CEST)

* Het is de bedoeling dat er een disclaimer bij de tabel komt te staan.
* Ik heb wel een paar boeken als leidraad gebruikt, die we als algemene bronvermelding kunnen noemen, maar voor de rest is er weinig literatuuronderbouwing voor de verschillende switches.
* Doelgroep van deze site zijn denk ik artsen (huisartsen/psychiaters) en apothekers --> zelfde doelgroep als voor psychiatrienet.nl.
mvg --[[User:Alexandra|Alexandra]] 14:58, 1 May 2009 (CEST)

== links ==

Dag Arent,

Er zijn een aantal links die niet helemaal kloppen, daar kwam ik achter met het invullen. Het gaat om een aantal SSRI's (paroxetine, sertraline, duloxetine etc) met nortriptyline. Ipv nortriptyline staat er namelijk citalopram onder. Zou je daar naar kunnen kijken?
Mvg, --[[User:Alexandra|Alexandra]] 21:51, 3 May 2009 (CEST)

: Is hersteld. Dank voor het opmerken - [[User:Musys|musys]] 11:19, 4 May 2009 (CEST)

Hoi Alexandra,

Hard gewerkt zie ik!

Nog maar een 'paar'rode linkjes in te vullen. Suc6 - [[User:Musys|musys]] 11:12, 6 May 2009 (CEST)

: Ja inderdaad. Op een gegeven moment heb je er een handigheid in en dan gaat het best snel. ;-)
: --[[User:Alexandra|Alexandra]] 11:20, 6 May 2009 (CEST)

== Sertraline-citalopram ==
In [[Sertraline-citalopram]] staat nu [[nortriptyline]] vermeld ... - [[User:Musys|musys]] 10:22, 7 May 2009 (CEST)

: Dank je. Ik heb het veranderd. --[[User:Alexandra|Alexandra]] 10:39, 7 May 2009 (CEST)

==Hypericum-venlafaxine==
Hoi Alexandra,

Nog eentje: in [[Hypericum-venlafaxine]] staat nu [[mirtazapine]] vermeld...

Bijna klaar! - [[User:Musys|musys]] 16:01, 7 May 2009 (CEST)

: Ik heb hem veranderd. En wat mij betreft ben ik klaar :)
: Mvg, --[[User:Alexandra|Alexandra]] 16:28, 7 May 2009 (CEST)

Sertraline-venlafaxine

2009-05-07T14:24:15Z

Alexandra:

{{Drugswitch
| from = sertraline
| to = venlafaxine
| stop =
* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to 25 mg/day.
* '''Day 8:''' stop administration of sertraline.
| start =
* No wash-out period is needed.
* '''Day 9:''' start venlafaxine the next day in normal dosage of 75 mg/day.}}

Sertraline-duloxetine

2009-05-07T14:23:37Z

Alexandra:

{{Drugswitch
| from = sertraline
| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to 25 mg/day.
* '''Day 8:''' stop administration of sertraline.
| start =
* No wash-out period is needed.
* '''Day 9:''' start duloxetine the next day in normal dosage of 60 mg/day.}}

Sertraline-duloxetine

2009-05-07T14:23:20Z

Alexandra:

{{Drugswitch
| from = sertraline
| to = duloxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to 25 mg/day.
* '''Day 8:'''stop administration of sertraline.
| start =
No wash-out period is needed.
* '''Day 9:''' start duloxetine the next day in normal dosage of 60 mg/day.}}