Psychiatrienet - User contributions [en]

Combining-Lithium-Gabapentin

2010-06-25T09:59:24Z

Mariska:

{{Drugcombi
| base = lithium
| add = gabapentin
| info =
* The advantages of gabapentin include the lack of interactions with other drugs in the cytochrome P450 system and the lack of protein binding. Since there is little risk of drug interactions, use with lithium is likely to be safe. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
| start =
* Start gabapentine according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-gabapentin-1147-0-1477-0|lithium|gabapentin}}</ref>
}}

Combining-Gabapentin-Lithium

2010-06-25T09:58:40Z

Mariska:

{{Drugcombi
| base = gabapentin
| add = lithium
| info = {{GabapentinAdvantage|lithium}}
| start =
* Start lithium according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-gabapentin-1147-0-1477-0|lithium|gabapentin}}</ref>
}}

Combining-Topiramate-Lithium

2010-06-25T09:57:01Z

Mariska:

{{Drugcombi
| base = topiramate
| add = lithium
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lithium according to the general dosing advice.
| cave =
* Elevated and toxic lithium levels have been reported with higher (800 mg/d) doses of topiramate, but not with 500 mg/d. <ref> {{Pubmed|12006910|Pinninti at al, Does topiramate elevate serum lithium levels? J Clin Psychopharmacol. 2002 Jun;22(3):340.}}</ref> <ref> {{Pubmed|15349023|Abraham at al, Topiramate can cause lithium toxicity. J Clin Psychopharmacol. 2004 Oct;24(5):565-7}}</ref>
* Pharmacologic response and serum lithium levels should be monitored closely in particular after change of dosage or discontinuation of topiramate.<ref name="drugscomint">
{{Drugscominteract|lithium-with-topiramate-1477-0-2216-0|lithium|topiramate}}</ref>
}}

Combining-Lithium-Topiramate

2010-06-25T09:56:07Z

Mariska:

{{Drugcombi
| base = lithium
| add = topiramate
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according to the general dosing advice.
| cave =
* Elevated and toxic lithium levels have been reported with higher (800 mg/d) doses of topiramate, but not with 500 mg/d. <ref> {{Pubmed|12006910|Pinninti at al, Does topiramate elevate serum lithium levels? J Clin Psychopharmacol. 2002 Jun;22(3):340.}}</ref> <ref> {{Pubmed|15349023|Abraham at al, Topiramate can cause lithium toxicity. J Clin Psychopharmacol. 2004 Oct;24(5):565-7}}</ref>
* Pharmacologic response and serum lithium levels should be monitored closely in particular after change of dosage or discontinuation of topiramate.<ref name="drugscomint">
{{Drugscominteract|lithium-with-topiramate-1477-0-2216-0|lithium|topiramate}}</ref>
}}

Combining-Topiramate-Lithium

2010-06-25T09:54:46Z

Mariska:

{{Drugcombi
| base = topiramate
| add = lithium
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lithium according to the general dosing advice.
| cave =
* Elevated and toxic lithium levels have been reported with higher (800 mg/d) doses of topiramate, but not with 500 mg/d. <ref> {{Pubmed|12006910|Pinninti at al, Does topiramate elevate serum lithium levels? J Clin Psychopharmacol. 2002 Jun;22(3):340.}}</ref> <ref> {{Pubmed|15349023|Abraham at al, Topiramate can cause lithium toxicity. J Clin Psychopharmacol. 2004 Oct;24(5):565-7}}</ref>
* Pharmacologic response and serum lithium levels should be monitored closely in particular after change of dosage or discontinuation of topiramate.<ref name="drugscomint">
{{Drugscominteract|lithium-with-gabapentin-1477-0-2216-0|lithium|gabapentin}}</ref>
}}

Combining-Topiramate-Lithium

2010-06-25T09:53:13Z

Mariska:

{{Drugcombi
| base = topiramate
| add = lithium
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lithium according to the general dosing advice.
| cave =
* Elevated and toxic lithium levels have been reported with higher (800 mg/d) doses of topiramate, but not with 500 mg/d. <ref> {{Pubmed|12006910|Pinninti at al, Does topiramate elevate serum lithium levels? J Clin Psychopharmacol. 2002 Jun;22(3):340.}}</ref> <ref> {{Pubmed|15349023|Abraham at al, Topiramate can cause lithium toxicity. J Clin Psychopharmacol. 2004 Oct;24(5):565-7}}</ref>
* Pharmacologic response and serum lithium levels should be monitored closely in particular after change of dosage or discontinuation of topiramate.<ref name="drugscomint">
{{Drugscominteract|lithium-with-gabapentin|1477-0-2216-0|lithium|gabapentin}}</ref>
}}

Combining-Lamotrigine-Lithium

2010-06-25T09:47:53Z

Mariska:

{{Drugcombi
| base = lamotrigine
| add = lithium
| info =
* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>
| cave = * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.<ref name="drugscominteract"> {{Drugscominteract|lamotrigine-with-lithium-1477-0-1430-0|lamotrigine|lithium}}</ref>
}}

Combining-Valproic acid-Quetiapine

2010-06-25T09:45:41Z

Mariska:

{{Drugcombi
| base = valproic acid
| add = quetiapine
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
| start =
* Start quetiapine according to the general dosing advice.
| cave =
* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref>
}}

Combining-Topiramate-Quetiapine

2010-06-25T09:44:35Z

Mariska:

{{Drugcombi
| base = topiramate
| add = quetiapine
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start quetiapine according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-topiramate-1979-1274-2216-1469|quetiapine|topiramate}}</ref>
}}

Combining-Lithium-Quetiapine

2010-06-25T09:43:21Z

Mariska:

{{Drugcombi
| base = lithium
| add = quetiapine
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
| start =
* Start quetiapine according to the general dosing advice.
| cave =
* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-lithium/1477-0-1979-1274|quetiapine|lithium}}</ref>
}}

Combining-Lamotrigine-Quetiapine

2010-06-25T09:42:26Z

Mariska:

{{Drugcombi
| base = lamotrigine
| add = quetiapine
| info =
| start =
* Start quetiapine according to the general dosing advice.
| cave =
}}

Combining-Gabapentin-Quetiapine

2010-06-25T09:41:22Z

Mariska:

{{Drugcombi
| base = gabapentin
| add = quetiapine
| info =
* {{CombiNoInteraction}}
| start =
* Start quetiapine according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-gabapentin-1147-0-1979-1274|quetiapine|gabapentin}}</ref>
}}

Combining-Quetiapine-Valproic acid

2010-06-25T09:40:03Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = valproic acid
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
| start =
* Start valproic acid according to the general dosing advice.
| cave =
* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-valproic-acid-1979-1274-2286-0|quetiapine|valproic acid}}</ref>
}}

Combining-Quetiapine-Topiramate

2010-06-25T09:39:08Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = topiramate
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-topiramate-1979-1274-2216-1469|quetiapine|topiramate}}</ref>
}}

Combining-Quetiapine-Lithium

2010-06-25T09:38:42Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = lithium
| info =
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. <ref> {{Pubmed|18579216|Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24}}</ref>
| start =
* Start lithium according to the general dosing advice.
| cave =
* During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-lithium/1477-0-1979-1274|quetiapine|lithium}}</ref>
}}

Combining-Quetiapine-Gabapentin

2010-06-25T09:37:02Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = gabapentin
| info =
* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.
| start =
* Start gabapentine according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscomint">
{{Drugscominteract|quetiapine-with-gabapentin-1147-0-1979-1274|quetiapine|gabapentin}}</ref>
}}

Combining-Ziprasidone-Quetiapine

2010-06-25T09:35:51Z

Mariska:

{{Drugcombi
| base = ziprasidone
| add = quetiapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. <ref name="drugscomint">
{{Drugscominteract|ziprasidone-with-quetiapine-2330-0-1979-0|ziprasidone|quetiapine}}</ref>
}}

Combining-Ziprasidone-Olanzapine

2010-06-25T09:35:24Z

Mariska:

{{Drugcombi
| base = ziprasidone
| add = olanzapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
{{Drugscominteract|ziprazidone-with-olanzapine-2330-0-1744-0|ziprazidone|olanzapine}}</ref>
}}

Combining-Ziprasidone-Aripiprazole

2010-06-25T09:31:17Z

Mariska:

{{Drugcombi
| base = aripiprazole
| add = ziprasidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination.<ref name="drugscom">
{{Drugscominteract|ziprasidone-with-aripiprazole-233-0-2330-0|ziprasidone|aripiprazole}}</ref>
}}

Combining-Quetiapine-Ziprasidone

2010-06-25T09:30:17Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = ziprasidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. <ref name="drugscomint">
{{Drugscominteract|ziprasidone-with-quetiapine-2330-0-1979-0|ziprasidone|quetiapine}}</ref>
}}

Combining-Quetiapine-Olanzapine

2010-06-25T09:29:35Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = olanzapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscominteract">
{{Drugscominteract|olanzapine-with-quetiapine-1979-1274-1744-1113|olanzapine|quetiapine}}</ref>
}}

Combining-Quetiapine-Risperidone

2010-06-25T09:27:49Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = risperidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. <ref name="drugscominteract">
{{Drugscominteract|risperidone-with-quetiapine-2019-1305-1979-1274|risperidone|quetiapine}}</ref>
}}

Combining-Quetiapine-Aripiprazole

2010-06-25T09:26:55Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = aripiprazole
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive (side)effects when used in combination. <ref name="drugscominteract">
{{Drugscominteract|quetiapine-with-aripiprazole-233-0-1979-0|quetiapine|aripiprazole}}</ref>
}}

Combining-Olanzapine-Ziprasidone

2010-06-25T09:25:50Z

Mariska:

{{Drugcombi
| base = olanzapine
| add = ziprasidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive (side)effects when used in combination. <ref name="drugscom">
{{Drugscominteract|ziprazidone-with-olanzapine-2330-0-1744-0|ziprazidone|olanzapine}}</ref>
}}

Combining-Lithium-Lamotrigine

2010-06-25T09:23:56Z

Mariska:

{{Drugcombi
| base = lithium
| add = lamotrigine
| info =
* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>
| cave = * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.<ref name="drugscominteract"> {{Drugscominteract|lamotrigine-with-lithium-1477-0-1430-0|lamotrigine|lithium}}</ref>
}}

Combining-Risperidone-Quetiapine

2010-06-25T09:23:15Z

Mariska:

{{Drugcombi
| base = risperidone
| add = quetiapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. <ref name="drugscominteract">
{{Drugscominteract|risperidone-with-quetiapine-2019-0-1979-0|risperidone|quetiapine}}</ref>
}}

Combining-Olanzapine-Quetiapine

2010-06-25T09:22:29Z

Mariska:

{{Drugcombi
| base = olanzapine
| add = quetiapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscominteract">
{{Drugscominteract|olanzapine-with-quetiapine-1979-0-1744-0|olanzapine|quetiapine}}</ref>
}}

Combining-Olanzapine-Risperidone

2010-06-25T09:18:49Z

Mariska:

{{Drugcombi
| base = olanzapine
| add = risperidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>
}}

Combining-Olanzapine-Aripiprazole

2010-06-25T09:18:08Z

Mariska:

{{Drugcombi
| base = olanzapine
| add = aripiprazole
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
{{Drugscominteract|aripiprazole-with-olanzapine-233-0-1744-0|aripiprazole|olanzapine}}</ref>
}}

Combining-Risperidone-Ziprasidone

2010-06-25T09:16:50Z

Mariska:

{{Drugcombi
| base = risperidone
| add = ziprasidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* The concurrent use of ziprasidone with other medications that can prolong the QT interval is considered contraindicated.<ref> {{Drugscominteract|risperidone-with-ziprasidone-2019-0-2330-0|risperidone|ziprasidone}}</ref>
}}

Combining-Risperidone-Quetiapine

2010-06-25T09:15:44Z

Mariska:

{{Drugcombi
| base = risperidone
| add = quetiapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. <ref name="drugscom">
{{Drugscominteract|risperidone-with-quetiapine-2019-0-1979-0|risperidone|quetiapine}}</ref>
}}

Combining-Risperidone-Olanzapine

2010-06-25T09:12:44Z

Mariska:

{{Drugcombi
| base = risperidone
| add = olanzapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive (side)effects when used in combination. <ref name="drugscom">
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>
}}

Combining-Risperidone-Valproic acid

2010-06-25T09:12:00Z

Mariska:

{{Drugcombi
| base = risperidone
| add = valproic acid
| info =
| start =
* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
* Start valproic acid according to the general dosing advice.
| cave =
* Dose-related generalised oedema is reported. <ref> {{Pubmed|9921707|Sanders and Lehrer, Edema associated with addition of risperidone to valproate treatment. J Clin Psychiatry. 1998 Dec;59(12):689-90.}}</ref>
* Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
}}

Combining-Risperidone-Olanzapine

2010-06-25T09:10:26Z

Mariska:

{{Drugcombi
| base = risperidone
| add = olanzapine
| info =
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* Agents with anticholinergic properties may have additive (side)effects when used in combination. <ref name="drugscom">
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>
}}

Combining-Risperidone-Olanzapine

2010-06-25T09:09:49Z

Mariska:

{{Drugcombi
| base = risperidone
| add = olanzapine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* Agents with anticholinergic properties may have additive (side)effects when used in combination. <ref name="drugscom">
{{Drugscominteract|risperidone-with-olanzapine|risperidone|olanzapine}}</ref>
}}

Combining-Risperidone-Aripiprazole

2010-06-25T09:07:40Z

Mariska:

{{Drugcombi
| base = aripiprazole
| add = risperidone
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination.<ref name="drugscom">
{{Drugscominteract|risperidone-with-aripiprazole-233-0-2019-0|risperidone|aripiprazole}}</ref>
}}

Combining-Aripiprazole-Ziprasidone

2010-06-25T09:06:07Z

Mariska:

{{Drugcombi
| base = ziprasidone
| add = aripiprazole
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination.<ref name="drugscom">
{{Drugscominteract|ziprasidone-with-aripiprazole-233-0-2330-0|ziprasidone|aripiprazole}}</ref>}}

Combining-Aripiprazole-Quetiapine

2010-06-25T09:05:18Z

Mariska:

{{Drugcombi
| base = aripiprazole
| add = quetiapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscomint">
{{Drugscominteract|aripiprazole-with-quetiapine-233-0-1979-0|aripiprazole|quetiapine}}</ref>
}}

Combining-Aripiprazole-Olanzapine

2010-06-25T09:04:25Z

Mariska:

{{Drugcombi
| base = aripiprazole
| add = olanzapine
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination. <ref name="drugscom">
{{Drugscominteract|aripiprazole-with-olanzapine-233-0-1744-0|aripiprazole|olanzapine}}</ref>
}}

Combining-Aripiprazole-Risperidone

2010-06-25T09:03:40Z

Mariska:

{{Drugcombi
| base = risperidone
| add = aripiprazole
| info =
| start =
{{IrrationalCombiAP}}
| cave =
* Agents with anticholinergic properties may have additive effects when used in combination.<ref name="drugscom">
{{Drugscominteract|risperidone-with-aripiprazole-233-0-2019-0|risperidone|aripiprazole}}</ref>
}}

Combining-Lithium-Lamotrigine

2010-06-22T14:42:44Z

Mariska:

{{Drugcombi
| base = lithium
| add = lamotrigine
| info =
* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>
| cave = * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.<ref name="drugscom"> {{Drugscominteract|lamotrigine-with-lithium-1477-0-1430-0|lamotrigine|lithium}}</ref>
}}

Combining-Lithium-Lamotrigine

2010-06-22T14:40:13Z

Mariska:

{{Drugcombi
| base = lithium
| add = lamotrigine
| info =
* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>
| cave = * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-lamotrigine-1430-0-1477-0|lithium|lamotrigine}}</ref>
}}

Combining-Lithium-Lamotrigine

2010-06-22T14:37:37Z

Mariska:

{{Drugcombi
| base = lithium
| add = lamotrigine
| info =
* This combination of drugs may be rational, but more data is needed.<ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Lamotrigine does not cause a significant change in the pharmacokinetics of lithium. Start lithium according to the general dosing advice. <ref> {{Pubmed| 10971302 |Chen C at al, The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000;50(3):193-5}}</ref>
| cave = * Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-lamotrigine|lithium|lamotrigine}}</ref>
}}

Combining-Carbamazepine-Lamotrigine

2010-06-22T14:05:21Z

Mariska:

{{Drugcombi
| base = carbamazepine
| add = lamotrigine
| info =  
| metabolites_ref = <ref name="informatorium">{{KNMP|carbamazepine}} </ref>
| start =
* Add lamotrigine according to the general dosing advice. Dose adjustment of carbamazepine is not necessary when lamotrigine is added.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref> <ref name="drugscomint">
{{Drugscominteract|lamotrigine-with-carbamazepine-1430-0-497-0|lamotrigine|carbamazepine}}</ref>
| cave =
{{CombiCaLa}}
}}

Combining-Lamotrigine-Carbamazepine

2010-06-22T14:04:04Z

Mariska:

{{Drugcombi
| base = lamotrigine
| add = carbamazepine
| info =  
| stop =
| start =
* Start carbamazepine with a daily dose of 200 mg and increase dose based on serum concentration if necessary. Check lamotrigine effect after 2 weeks of therapy and adapt dose if necessary.<ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name="drugscomint">
{{Drugscominteract|lamotrigine-with-carbamazepine-1430-0-497-0|lamotrigine|carbamazepine}}</ref>
| cave = {{CombiCaLa}}
}}

Combining-Carbamazepine-Quetiapine

2010-06-18T13:26:03Z

Mariska:

{{Drugcombi
| base = carbamazepine
| add = quetiapine
| info =  
| start =
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
* Add quetiapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> <ref name="drugscomint">
{{Drugscominteract|carbamazepine-with-quetiapine-497-0-1979-0|carbamazepine|quetiapine}}</ref>
| cave =
}}

Combining-Quetiapine-Carbamazepine

2010-06-18T13:24:44Z

Mariska:

{{Drugcombi
| base = quetiapine
| add = carbamazepine
| info =
* {{PossibleSynergisticEffects}}
| start =
* Start carbamazepine according to the general dosing advice.
* The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.<ref name="drugscomint">
{{Drugscominteract|carbamazepine-with-quetiapine-497-0-1979-0|carbamazepine|quetiapine}}</ref>
| cave =
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
}}

Combining-Topiramate-Carbamazepine

2010-06-18T11:33:29Z

Mariska:

{{Drugcombi
| base = topiramate
| add = carbamazepine
| info =  
| start =
* Carbamazepine can increase topiramate clearance. By adding topiramate to carbamazepine no dose adaptation is necessary. <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name="drugscomint">
{{Drugscominteract|carbamazepine-with-topiramate-2216-0-497-0|carbamazepine|topiramate}}</ref>
| cave =
* This combination of drugs is subject to pharmacokinetic drug interactions. Discontinuation or dose reduction of either drug will need monitoring of the clinical effects and dose adaptation of the drug remained.
}}

Combining-Carbamazepine-Topiramate

2010-06-18T11:32:41Z

Mariska:

{{Drugcombi
| base = carbamazepine
| add = topiramate
| info =  
| start =
* Carbamazepine can increase topiramate clearance. By adding topiramate to carbamazepine no dose adaptation is necessary. <ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name="drugscomint">
{{Drugscominteract|carbamazepine-with-topiramate-2216-0-497-0|carbamazepine|topiramate}}</ref>
| cave =
* This combination of drugs is subject to pharmacokinetic drug interactions. Discontinuation or dose reduction of either drug will need monitoring of the clinical effects and dose adaptation of the drug remained.
}}

Combining-Lithium-Carbamazepine

2010-06-18T11:28:19Z

Mariska:

{{Drugcombi
| base = lithium
| add = carbamazepine
| info =
* The addition of carbamazepine allowes patients to function better while maintaining lower lithium levels.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
* The available data suggest that the combination of lithium and carbamazepine is safe and effective, especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
* Lithium and carbamazepine may work synergistically.<ref name="freeman"/>
* Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/>
| start =
* Start carbamazepine according to the general dosing advice.
| cave = {{CombiCaLi}}
}}