Psychiatrienet - User contributions [en]

Clozapine-Lurasidone

2015-03-05T12:57:46Z

Roland:

{{Drugswitch
| from = Clozapine
| to = Lurasidon
| stop =
* '''Day 1:''' gradually reduce the dose of haloperidol with 12,5-25 mg a week <ref>[http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1415944617205.pdf MHRA. SmPC Clozaril 100 mg tablets.]</ref>
| start =
* '''Week 1:''' approx. 25% of target dose
* '''Week 2:''' approx. 50% of target dose
* '''Week 3:''' approx. 75% of target dose
* '''Week 4:''' target dose
| info = {{ClozEffect}} {{caveQT}}
}}

Clozapine-Lurasidone

2015-03-05T12:46:28Z

Roland: Created page with '{{Drugswitch | from = Clozapine | to = Lurasidon | stop = * '''Day 1:''' gradually reduce the dose of haloperidol with 12,5 mg a week | start = * '''Week 1:''' approx. 25% of...'

{{Drugswitch
| from = Clozapine
| to = Lurasidon
| stop =
* '''Day 1:''' gradually reduce the dose of haloperidol with 12,5 mg a week
| start =
* '''Week 1:''' approx. 25% of target dose
* '''Week 2:''' approx. 50% of target dose
* '''Week 3:''' approx. 75% of target dose
* '''Week 4:''' target dose
| info = {{ClozEffect}} {{caveQT}}
}}

Sertindole-Lurasidone

2015-03-05T12:37:53Z

Roland: Created page with '{{Drugswitch | from = Sertindole | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of sertindole to 50% of the dose. * '''Day 8-14:''' gradually reduce the d...'

{{Drugswitch
| from = Sertindole
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of sertindole to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of sertindole to 0% of the dose
* '''Day 14:''' stop administration of sertindole.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
| info = {{caveQT}}
}}

Amisulpride-Lurasidone

2015-03-05T12:37:00Z

Roland:

{{Drugswitch
| from = Amisulpride
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of amisulpride to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of amisulpride to 0% of the dose
* '''Day 14:''' stop administration of amisulpride.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
| info = {{caveQT}}
}}

Amisulpride-Lurasidone

2015-03-05T12:36:37Z

Roland: Created page with '{{Drugswitch | from = Amisulpride | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of pimozide to 50% of the dose. * '''Day 8-14:''' gradually reduce the do...'

{{Drugswitch
| from = Amisulpride
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of pimozide to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of pimozide to 0% of the dose
* '''Day 14:''' stop administration of pimozide.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
| info = {{caveQT}}
}}

Sulpiride-Lurasidone

2015-03-05T12:28:58Z

Roland: Created page with '{{Drugswitch | from = Sulpiride | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of sulpiride to 50% of the dose. * '''Day 8-14:''' gradually reduce the dos...'

{{Drugswitch
| from = Sulpiride
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of sulpiride to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of sulpiride to 0% of the dose
* '''Day 14:''' stop administration of sulpiride.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
| info = {{caveQT}}
}}

Pimozide-Lurasidone

2015-03-05T12:27:51Z

Roland: Created page with '{{Drugswitch | from = Pimozide | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of pimozide to 50% of the dose. * '''Day 8-14:''' gradually reduce the dose ...'

{{Drugswitch
| from = Pimozide
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of pimozide to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of pimozide to 0% of the dose
* '''Day 14:''' stop administration of pimozide.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
| info = {{caveQT}}
}}

Chlorpromazine-Lurasidone

2015-03-05T12:20:50Z

Roland: Created page with '{{Drugswitch | from = Chlorpromazine | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of chlorpromazine to 50% of the dose. * '''Day 8-14:''' gradually redu...'

{{Drugswitch
| from = Chlorpromazine
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of chlorpromazine to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of chlorpromazine to 0% of the dose
* '''Day 14:''' stop administration of chlorpromazine.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Haloperidol-Lurasidone

2015-03-05T12:19:37Z

Roland: Created page with '{{Drugswitch | from = Haloperidol | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of haloperidol to 50% of the dose. * '''Day 8-14:''' gradually reduce the...'

{{Drugswitch
| from = Haloperidol
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of haloperidol to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of haloperidol to 0% of the dose
* '''Day 14:''' stop administration of haloperidol.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Ziprasidone-Lurasidone

2015-03-05T12:18:03Z

Roland: Created page with '{{Drugswitch | from = Ziprasidone | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of aiprasidone to 50% of the dose. * '''Day 8-14:''' gradually reduce the...'

{{Drugswitch
| from = Ziprasidone
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of aiprasidone to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of ziprasidone to 0% of the dose
* '''Day 14:''' stop administration of ziprasidone.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Risperidone-Lurasidone

2015-03-05T12:16:59Z

Roland: Created page with '{{Drugswitch | from = Risperidone | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of risperidone to 50% of the dose. * '''Day 8-14:''' gradually reduce the...'

{{Drugswitch
| from = Risperidone
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of risperidone to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of risperidone to 0% of the dose
* '''Day 14:''' stop administration of risperidone.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Aripiprazole-Lurasidone

2015-03-05T12:16:00Z

Roland:

{{Drugswitch
| from = Aripiprazole
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of aripiprazole to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of aripiprazole to 0% of the dose
* '''Day 14:''' stop administration of aripiprazol.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Quetiapine-Lurasidone

2015-03-05T12:15:17Z

Roland:

{{Drugswitch
| from = Quetiapine
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of quetiapine to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of queatipne to 0% of the dose
* '''Day 14:''' stop administration of quetiapine.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Olanzapine-Lurasidone

2015-03-05T12:14:45Z

Roland:

{{Drugswitch
| from = Olanzapine
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of olanzapine to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of olanzapine to 0% of the dose
* '''Day 14:''' stop administration of olanzapine.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Quetiapine-Lurasidone

2015-03-05T12:12:54Z

Roland: Created page with '{{Drugswitch | from = Quetiapine | to = Lurasidon | stop = * '''Day 1-7:''' gradually reduce the dose of quetiapine to 50% of the dose. * '''Day 8-14:''' gradually reduce the d...'

{{Drugswitch
| from = Quetiapine
| to = Lurasidon
| stop =
* '''Day 1-7:''' gradually reduce the dose of quetiapine to 50% of the dose.
* '''Day 8-14:''' gradually reduce the dose of queatipne to 25% of the dose
* '''Day 15:''' stop administration of quetiapine.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Olanzapine-Lurasidone

2015-03-05T11:35:27Z

Roland: Created page with '{{Drugswitch | from = Olanzapine | to = Lurasidon | stop = * '''Day 1-7:''' reduce the dose of olanzapine to 50% of the dose. * '''Day 14:''' stop administration of olanzapine....'

{{Drugswitch
| from = Olanzapine
| to = Lurasidon
| stop =
* '''Day 1-7:''' reduce the dose of olanzapine to 50% of the dose.
* '''Day 14:''' stop administration of olanzapine.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Aripiprazole-Lurasidone

2015-03-05T11:34:32Z

Roland:

{{Drugswitch
| from = Aripiprazole
| to = Lurasidon
| stop =
* '''Day 1-7:''' reduce the dose of aripiprazol to 50% of the dose.
* '''Day 14:''' stop administration of aripiprazol.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
}}

Aripiprazole-Lurasidone

2015-03-05T11:33:42Z

Roland:

{{Drugswitch
| from = Aripiprazole
| to = Lurasidon
| stop =
* '''Day 1-7:''' reduce the dose of aripiprazol to 50% of the dose.
* '''Day 14:''' stop administration of aripiprazol.
| start =
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
| info = {{caveQT}}
* It is also possible to start administration of lurasidon in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>

}}

Aripiprazole-Lurasidone

2015-03-05T11:28:57Z

Roland:

Aripiprazole-Lurasidone

2015-03-05T11:28:29Z

Roland: Created page with '{{Drugswitch | from = Aripiprazole | to = Lurasidon | stop = * '''Day 1-7:''' reduce the dose of aripiprazol to 50% of the dose. * '''Day 14:''' stop administration of aripipra...'

Vortioxetine-citalopram

2015-03-04T15:53:01Z

Roland:

{{Drugswitch
| from = vortioxetine
| to = citalopram
| stop =
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.
* '''Day 7:''' stop administration of vortioxetine.
| start =
* No wash-out period is needed.
* Start citalopram the next day in normal dosage of 20 mg/day.
| info =
* {{theorSS}}<ref>[http://www.ema.europa.eu/docs/nl_NL/document_library/EPAR_-_Product_Information/human/002717/WC500159449.pdf European Medicines Agency. SmPC Brintellix 5 mg.]</ref>
}}

Trazodone-vortioxetine

2015-03-04T15:50:03Z

Roland:

{{Drugswitch
| from = trazodone
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce the dosage of trazodone to 75-100 mg/day.
* '''Day 8:''' when a dosage of 75 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Duloxetine-vortioxetine

2015-03-04T15:49:36Z

Roland:

{{Drugswitch
| from = duloxetine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day, when this dosage is > 60 mg/day.
* '''Day 1-7:''' reduce dosage of duloxetine from 60 mg/day to 30 mg/day
* '''Day 8-14:''' reduce dosage of duloxetine to 30 mg/day to 0 mg/day
* '''Day 15:''' stop administration of duloxetine.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 15:''' Start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Venlafaxine-vortioxetine

2015-03-04T15:48:42Z

Roland:

{{Drugswitch
| from = venlafaxine
| to = vortioxetine
| stop =
{{downVenla}}
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Venlafaxine-vortioxetine

2015-03-04T15:48:33Z

Roland:

{{Drugswitch
| from = venlafaxine
| to = vortioxetine
| stop =
{{downVenla}}
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Venlafaxine-vortioxetine

2015-03-04T15:47:51Z

Roland:

{{Drugswitch
| from = venlafaxine
| to = vortioxetine
| stop =
{{downVenla}}
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info:
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Sertraline-vortioxetine

2015-03-04T15:47:30Z

Roland:

{{Drugswitch
| from = sertraline
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 15 mg/day, when this dosage is > 50 mg/day.
* '''Day 1:''' when a dosage of 50 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Paroxetine-vortioxetine

2015-03-04T15:47:02Z

Roland:

{{Drugswitch
| from = paroxetine
| to = vortioxetine
| stop =
{{downparox}}
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Fluvoxamine-vortioxetine

2015-03-04T15:46:37Z

Roland:

{{Drugswitch
| from = fluvoxamine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
* '''Day 1:''' when a dosage of 50 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Fluvoxamine is a strong inhibitor of CYP2C9, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Fluoxetine-vortioxetine

2015-03-04T15:46:08Z

Roland:

{{Drugswitch
| from = fluoxetine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Escitalopram-vortioxetine

2015-03-04T15:45:50Z

Roland:

{{Drugswitch
| from = escitalopram
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary, , but care is needed.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Escitalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Citalopram-vortioxetine

2015-03-04T15:45:30Z

Roland:

{{Drugswitch
| from = citalopram
| to = vortioxetine
| stop =
* '''Before day 1:''' Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
* '''Day 1:''' When a dosage of 20 mg/day is reached, stop administration.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 1:''' Start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Fluoxetine-vortioxetine

2015-03-04T15:44:00Z

Roland:

{{Drugswitch
| from = fluoxetine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after intiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Escitalopram-vortioxetine

2015-03-04T15:43:03Z

Roland:

{{Drugswitch
| from = escitalopram
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
| start =
* A wash-out period is not necessary, , but care is needed.
* '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Escitalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after intiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Citalopram-vortioxetine

2015-03-04T15:41:17Z

Roland:

{{Drugswitch
| from = citalopram
| to = vortioxetine
| stop =
* '''Before day 1:''' Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
* '''Day 1:''' When a dosage of 20 mg/day is reached, stop administration.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 1:''' Start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine.
* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after intiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}

Venlafaxine-vortioxetine

2015-03-04T15:24:48Z

Roland:

Trazodone-vortioxetine

2015-03-04T15:21:59Z

Roland:

Tranylcypromine-vortioxetine

2015-03-04T15:17:10Z

Roland:

{{Drugswitch
| from = tranylcypromine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of tranylcypromine with 10-20 mg/week.
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
| start =
* '''Day 1-14:''' a wash-out period of two weeks is necessary.
* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* The wash-out period is necessary for the MAO enzymes to restore their function.
}}

Paroxetine-vortioxetine

2015-03-04T15:14:31Z

Roland:

Sertraline-vortioxetine

2015-03-04T15:13:46Z

Roland:

Paroxetine-vortioxetine

2015-03-04T15:11:52Z

Roland:

Nortriptyline-vortioxetine

2015-03-04T15:09:24Z

Roland:

{{Drugswitch
| from = nortriptyline
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
* '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day.
* '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day.
* '''Day 8:''' stop administration of nortriptyline.
| start =
* A wash-out period is not necessary.
* '''Day 1:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
}}

Citalopram-vortioxetine

2015-03-04T15:05:05Z

Roland:

Escitalopram-vortioxetine

2015-03-04T15:04:49Z

Roland:

Citalopram-vortioxetine

2015-03-04T15:01:22Z

Roland:

Moclobemide-vortioxetine

2015-03-04T14:58:38Z

Roland:

{{Drugswitch
| from = moclobemide
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* '''Day 8-9:''' a wash-out period of two days is necessary.
* '''Day 10:''' start administration of vortioxetine in a normale dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}

Moclobemide-vortioxetine

2015-03-04T14:58:27Z

Roland:

{{Drugswitch
| from = moclobemide
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day.
* '''Day 1:''' reduce the dosage of moclobemide to 150 mg/day.
* '''Day 8:''' stop administration of moclobemide.
| start =
* A wash-out period is not necessary.
* '''Day 8-9:''' a wash-out period of two days is necessary.
* '''Day 10:''' start administration of vortioxetine in a normale dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}

Mirtazapine-vortioxetine

2015-03-04T14:54:00Z

Roland:

{{Drugswitch
| from = mirtazapine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
* '''Day 1:''' reduce the dosage of 30 mg/day to 15 mg/day.
* '''Day 8:''' stop administration of mirtazapine.
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}

Maprotiline-vortioxetine

2015-03-04T14:41:49Z

Roland:

{{Drugswitch
| from = maprotiline
| to = vortioxetine
| stop =
| stop =
* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.
* '''Day 8:''' reduce dosage of maprotiline to 25 mg/day.
* '''Day 14:''' stop dosage of maprotiline.
| start =
* A wash-out period is not necessary.
* '''Day 15:''' start administration of vortioxetine in a dosage of 10 mg/day.
}}

Imipramine-vortioxetine

2015-03-04T14:34:10Z

Roland:

{{Drugswitch
| from = imipramine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
* '''Day 8:''' stop administration of imipramine.
| start =
* A wash-out period is not necessary.
* '''Day 8:''' start administration of vortioxetine in a dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}