* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day. {{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day. * '''Day {{StartAgomelatine|8:''' stop administration of venlafaxine and continue administration of amitriptyline in a dosage of 50 mg/day.| info = * “Start low, go slow” for amitriptyline, and caution with this switch is necessary. }}* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.}}