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| from = vortioxetine
| to = sertraline
| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = * A wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions.* '''Day 15:''' Start sertraline in a normal dosage of 50 mg/day. {{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose sertraline = 100 mg* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}