| stop = {{stopVortioxetineStopSSRI,SNRI}}| start = * ''' Day 8-14: ''' a wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions.* '''Day 15:''' Start sertraline in a normal dosage of 50 mg/day. {{StartAntidepressant}}| info = * {{theorSS}}Safe target dose sertraline = 100 mg* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}