| to = paroxetine
| stop =
{{stopVortioxetineTCAdecrease25p3d}}
| start =
{{washout8* '''Day 7 and after''': At approximately 50-14}}25% of the original vortioxetine dose start paroxetine at 50% of the target dose.* '''Day 1514:''' start administration of Increase paroxetine in a normal dosage to 100% of 10-20 mg/day. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>the target dose
| info =
* {{theorSS}}Safe target dose paroxetine = 20 mg* Paroxetine paroxetine is a strong CYP2D6 inhibitor of CYP2D6, which metabolizes metabolize vortioxetine. }}
