* '''Day 15:''' start administration of imipramine in a low dosage of 25 mg/day.* '''Day 815:''' increase dosage of imipramine to 50 mg/day.* '''Day 1520 and after:''' gradually increase dosage of imipramine to 75 mg/dayif necessary.

* {{TCAplasmalevelmonitoring}}* Tapering fluoxetine to 20mg before stopping is not necessary, because of strong serotonergic activity of target drug.{{longt1/2fluvox}}* Fluoxetine slows and norfluoxetine slow the metabolism of imipramine via CYP2D6. * Start low, go slow for imipramine.}}