Difference between revisions of "Fluvoxamine-amitriptyline"
From Psychiatrienet
(Created page with '{{Drugswitch | from = fluvoxamine | to = amitriptyline | stop = * '''Day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/d...') |
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| Line 3: | Line 3: | ||
| to = amitriptyline | | to = amitriptyline | ||
| stop = | | stop = | ||
| − | * '''Day 0:''' gradually reduce dosage of fluvoxamine to a maximum of | + | * '''Day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day. |
| − | * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of | + | * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 50 mg/day. |
| + | * '''Day 8:''' stop administration of fluvoxamine | ||
| start = | | start = | ||
Caution is necessary. | Caution is necessary. | ||
* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day. | ||
| − | * '''Day 8:''' | + | * '''Day 8:''' continue administration of amitriptyline in a dosage of 50 mg/day. |
* Start low, go slow! | * Start low, go slow! | ||
| info = | | info = | ||
* Fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6.}} | * Fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6.}} | ||
Revision as of 13:07, 5 June 2009
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Switch medication from fluvoxamine to amitriptyline.[1] [2]
Stop fluvoxamine - Day 0: gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day.
- Day 1: reduce dosage of fluvoxamine to a maximum of 50 mg/day.
- Day 8: stop administration of fluvoxamine
Start amitriptylineCaution is necessary.
- Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
- Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
- Start low, go slow!
More information- Fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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