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Trazodone-sertraline

108 bytes removed, 12:40, 10 July 2009
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* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
* '''Day 1:''' reduce dosage of trazodone to 75 -100 mg/day.
* '''Day 8:''' stop administration of trazodone.
* '''Day 8-13:''' wash-out period
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* A wash-out period is not necessary, but care is needed.* '''Day 814:''' start administration of sertraline in a normal dosage of 50 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.}}
Walter
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