Difference between revisions of "Hypericum-doxepine"
From Psychiatrienet
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* '''Day 31:''' start doxepin 25 mg/day. | * '''Day 31:''' start doxepin 25 mg/day. | ||
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* Occurrence of the serotonin syndrome is possible without wash-out period. | * Occurrence of the serotonin syndrome is possible without wash-out period. | ||
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Revision as of 10:55, 15 July 2009
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Switch medication from hypericum to doxepin.[2] [3]
Stop hypericum - Day 1-14:Gradually decrease the dosage of hypericum.
- Day 15: stop administration of hypericum.
Start doxepin- Day 15-30: a wash-out period of at least two weeks is necessary.
- Day 31: start doxepin 25 mg/day.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
More information- Hypericum induces enzymes of the CYP P-450 type and P-gp type.
- Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
- Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[4]
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.
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