Difference between revisions of "Clomipramine-venlafaxine"
From Psychiatrienet
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* '''Day 3:''' reduce dosage of clomipramine to 25 mg/day. | * '''Day 3:''' reduce dosage of clomipramine to 25 mg/day. | ||
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| − | * '''Day 1:''' simultaneously | + | * '''Day 1:''' simultaneously {{startVenla}} |
* '''Day 8:''' stop administration of clomipramine and continue administration of venlafaxine. | * '''Day 8:''' stop administration of clomipramine and continue administration of venlafaxine. | ||
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}} | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}} | ||
Revision as of 08:01, 20 July 2009
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Switch medication from clomipramine to venlafaxine.[1] [2]
Stop clomipramine - Before day 0: gradually reduce dosage of clomipramine to a maximum of 75 mg/day.
- Day 1: reduce dosage of clomipramine to 50 mg/day.
- Day 3: reduce dosage of clomipramine to 25 mg/day.
Start venlafaxine- Day 1: simultaneously Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
- Day 8: stop administration of clomipramine and continue administration of venlafaxine.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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