Difference between revisions of "Duloxetine-fluvoxamine"
From Psychiatrienet
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| − | * | + | * '''Before day 0:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/ day. |
| − | * | + | * '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. |
| − | | start = | + | * '''Day 7:''' stop duloxetine. |
| − | * | + | | start = |
| − | * | + | * '''Day 10:''' start fluvoxamine 50 mg. |
| + | * '''Day 14:''' increase administration of fluvoxamine. | ||
| + | | info = | ||
| + | * Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2. | ||
| + | * {{theorSS}} | ||
| + | }} | ||
Revision as of 08:22, 3 August 2009
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Switch medication from duloxetine to fluvoxamine.[1] [2]
Stop duloxetine - Before day 0: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
- Day 7: stop duloxetine.
Start fluvoxamine- Day 10: start fluvoxamine 50 mg.
- Day 14: increase administration of fluvoxamine.
More information- Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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