Difference between revisions of "Clomipramine-agomelatine"
From Psychiatrienet
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| to = agomelatine | | to = agomelatine | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day. |
* '''Day 1:''' reduce dosage of clomipramine to 50 mg/day. | * '''Day 1:''' reduce dosage of clomipramine to 50 mg/day. | ||
* '''Day 8:''' reduce dosage of clomipramine to 25 mg/day. | * '''Day 8:''' reduce dosage of clomipramine to 25 mg/day. | ||
Revision as of 15:16, 11 September 2009
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Switch medication from clomipramine to agomelatine.[1] [2]
Stop clomipramine - Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/day, when this dosage is > 75 mg/day.
- Day 1: reduce dosage of clomipramine to 50 mg/day.
- Day 8: reduce dosage of clomipramine to 25 mg/day.
- Day 15: stop administration of clomipramine.
Start agomelatine- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
- Day 15: If necessary, increase dosage of agomelatine to 50 mg/day.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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