Difference between revisions of "Mianserine-clomipramine"
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| to = clomipramine | | to = clomipramine | ||
| stop = | | stop = | ||
| − | * ''' | + | * '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day. |
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. | * '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day. | ||
| start = | | start = | ||
No wash-out period is needed. | No wash-out period is needed. | ||
* '''Day 1:''' simultaneously start administration of clomipramine in a dosage of 50 mg/day. | * '''Day 1:''' simultaneously start administration of clomipramine in a dosage of 50 mg/day. | ||
| − | * '''Day 8:''' stop administration of mianserine and continue administration of clomipramine | + | * '''Day 8:''' stop administration of mianserine and continue administration of clomipramine in a dosage of 75 mg/day. If necessary, increase the dosage of clomipramine. |
| − | in a dosage of 75 mg/day. | ||
| − | |||
* Start low, go slow.}} | * Start low, go slow.}} | ||
Latest revision as of 15:07, 17 November 2009
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Switch medication from mianserine to clomipramine.[1] [2]
Stop mianserine - Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Start clomipramineNo wash-out period is needed.
- Day 1: simultaneously start administration of clomipramine in a dosage of 50 mg/day.
- Day 8: stop administration of mianserine and continue administration of clomipramine in a dosage of 75 mg/day. If necessary, increase the dosage of clomipramine.
- Start low, go slow.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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